Journal article
Effect of nutrient supplementation on the acquisition of humoral immunity to Plasmodium falciparum in young Malawian children NCT01239693 NCT
P Barua, UP Chandrasiri, JG Beeson, KG Dewey, K Maleta, P Ashorn, SJ Rogerson
Malaria Journal | BIOMED CENTRAL LTD | Published : 2018
Abstract
Background: There is evidence that suggests that undernutrition has a detrimental effect on malarial immunity in children. The aim of the study was to discover whether nutrient supplementation improved development of malarial antibody immunity in children up to 18 months of age. Methods: The study was conducted with a subset of 432 Malawian children from a randomized controlled trial of nutritional supplements. The arms included pre- and postnatal small-quantity lipid-based nutrient supplements for both mother and child; prenatal supplementation with iron and folic acid; and pre- and postnatal supplementation with multiple micronutrients. Paired plasma samples were collected at 6 and 18 mont..
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Awarded by Academy of Finland
Funding Acknowledgements
This publication is based on research funded in part by a grant from the Office of Health, Infectious Diseases, and Nutrition, Bureau for Global Health, U.S. Agency for International Development (USAID) under terms of Cooperative Agreement No. AID-OAA-A-12-00005, through the Food and Nutrition Technical Assistance III Project (FANTA), managed by FHI 360. Additional funding was obtained from a grant to the University of California, Davis from the Bill & Melinda Gates Foundation and the Academy of Finland. SJR and JGB are supported by a Program Grant from the National Health and Medical Research Council of Australia (NHMRC) and JGB is supported by an NHMRC Senior Research Fellowship. The Burnet Institute is supported by the NHMRC IRIIS Scheme and Victorian State Government Operational Infrastructure Support.